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Youth-onset type 2 diabetes (T2D) poses unique challenges, and this study sheds light on how common treatments like metformin and liraglutide impact the gut microbiome. Understanding these shifts may allow for more targeted therapies and improved outcomes i...
In cardiology, physician receipt of industry payments was associated with prescribing patterns for PCSK9 inhibitors, angiotensin receptor neprilysin inhibitors, and direct oral anticoagulants in an analysis from the NCDR PINNACLE registry. The direction and...
Patisiran for hereditary transthyretin amyloidosis polyneuropathy in V122I and T60A genotypes is reported with variant-specific outcomes. Findings describe measurable changes in neurologic function and patient-reported domains under routine multicenter cond...
Postoperative pneumonia after cardiopulmonary bypass remains common and costly. In a prospective randomized proof-of-concept trial, high-dose inhaled nitric oxide was delivered perioperatively to prevent nosocomial infection. Feasibility and safety were dem...
Elderly Ukrainians displaced to Israel face high burdens of chronic disease and care continuity challenges. A new retrospective cohort characterizes patterns across primary care, emergency, inpatient, and prescriptions, highlighting concentrated demand soon...
Pregnancy complications are shaped by care quality as much as clinical risks. New data from urban Dar es Salaam describe the prevalence and determinants of respectful childbirth, highlighting how provider behaviors and facility readiness, including the one ...
An Expression of Concern has been posted regarding work in somatotroph adenomas that linked CDKN2A (p16INK4A) to CDK inhibitors response. Because p16INK4A modulates cell cycle control, any claim that it alters anti-tumor activity is clinically relevant. The...
A large genetic analysis in asthma and nasal polyposis reports 131 loci , pointing to immune pathways and tissue-specific signals in airway biology. The findings emphasize mechanisms rooted in barrier-immune crosstalk and inflammatory signaling, underscorin...
In metabolic dysfunction-associated steatotic liver disease (MASLD), use of aspirin alone was associated with differences in risks of all-cause mortality and liver-related events over three years in a multi-institutional analysis. Findings are observational...
In a general US cohort, higher baseline cystatin C, a filtration biomarker independent of muscle mass, tracked with increased all-cause and cardiovascular mortality over 20 years. Associations persisted after adjustment for creatinine-based eGFR and risk fa...