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Cancers driven by tropomyosin 3 (TPM3) gene fusions represent a therapeutic challenge, with resistance mechanisms poorly understood. A comprehensive review highlights the pressing need for improved preclinical models and a deeper understanding of downstream...
Identifying TRK fusion -positive cancers is critical, as targeted therapies offer significant benefits. Oncologists should proactively integrate appropriate testing strategies into their practice to ensure patients receive optimal, personalized treatment.
Lysine sorbylation, a metabolite-derived acylation, extends the posttranslational modification repertoire by linking cellular metabolism to protein regulation. Initial signals suggest histone and nonhistone targets, potential competition with other acyl mar...
In colorectal neoplasms care, drug exposure can rarely trigger insulin autoimmune syndrome, where autoantibodies bind insulin and cause unpredictable postprandial hypoglycemia. The key signal is therapy-associated autoimmune hypoglycemia with markedly eleva...
In colorectal neoplasms care, drug-induced insulin autoimmune syndrome can present with recurrent hypoglycemia driven by insulin autoantibodies that bind and later release endogenous insulin. This case highlights the mechanism, diagnostic pathway using insu...
Insulin autoimmune syndrome in colorectal cancer care presents as recurrent hypoglycemia driven by insulin autoantibodies that bind and unpredictably release endogenous insulin. A case from oncology highlights that implicated medications can trigger this me...
In prostatic neoplasms treated with radiation , endarteritis and tissue fibrosis can culminate in a rectoprostatic fistula. This report underscores that a robotic-assisted repair is feasible, leveraging enhanced pelvic visualization for multilayer closure a...
In prostatic neoplasms, radiation can precipitate a rectoprostatic fistula through tissue ischemia and fibrosis that destabilize the rectal and urethral walls. Robotic multilayer repair with vascularized interposition offers a feasible path to closure. The ...
In prostatic neoplasms, rectoprostatic fistula after brachytherapy reflects radiation-related tissue injury that complicates dissection and healing. A robotic-assisted approach enabled precise mobilization in irradiated planes, layered closure, and tissue p...
Across breast pathology, adipocytes contribute key cues to the tumor microenvironment that can influence interpretation. A curated compendium catalogs and defines distinctive adipocyte morphologies with microanatomic context, offering a shared lexicon for p...