Alzheimer Disease

PARP1 Deficiency Reduces Amyloid Pathology in Familial AD Model

New preclinical work links PARP1 deficiency to reduced amyloid burden and cognitive preservation in a familial Alzheimer's model.

Gut Microbiota Signal the Brain via the Vagus Nerve: What GPs Should Know

The gut-brain axis operates partly through vagal afferent neurons. Here is what the established mechanistic evidence means for everyday practice.

Low-Dose Lithium for Cognitive Decline: What the Evidence Actually Shows

Lithium at sub-therapeutic doses has been studied as a neuroprotective agent in dementia prevention, but the clinical evidence remains thin and inconsistent.