Neurology

PARP1 Deficiency Reduces Amyloid Pathology in Familial AD Model

New preclinical work links PARP1 deficiency to reduced amyloid burden and cognitive preservation in a familial Alzheimer's model.

Brain Cooling After Thrombectomy: Does Hypothermia Aid LVO Recovery?

Targeted temperature management after mechanical thrombectomy for LVO stroke is under active investigation, but the evidence base remains preliminary.

Gut Microbiota Signal the Brain via the Vagus Nerve: What GPs Should Know

The gut-brain axis operates partly through vagal afferent neurons. Here is what the established mechanistic evidence means for everyday practice.

Low-Dose Lithium for Cognitive Decline: What the Evidence Actually Shows

Lithium at sub-therapeutic doses has been studied as a neuroprotective agent in dementia prevention, but the clinical evidence remains thin and inconsistent.

Parkinson's Neuroprotection 2025: Three Strategies Under Review

Stem cell therapy, System Xc- pathway modulation, and Ayurvedic add-on regimens are each being evaluated as neuroprotective strategies in Parkinson's disease.