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Addressing depression in chronic care settings is vital for improving patient outcomes. Culturally relevant screening programs may optimize the identification of at-risk individuals and facilitate access to appropriate mental health services.
Patients co-infected with HIV and hypertension in South Africa face significant out-of-pocket expenditures, jeopardizing treatment adherence. Integrating non-communicable disease (NCD) care into existing HIV programs is an economic imperative to alleviate p...
Infants with non-severe combined immunodeficiency (SCID) T-cell lymphopenia detected via newborn screening present a diagnostic and management challenge. This cohort study highlights the need for further prospective research to understand the long-term clin...
A novel *SPI1* mutation was identified in a Chinese patient with agammaglobulinemia, but the evidence for causality remains weak. Clinicians should be wary of attributing rare genetic variants to disease without robust functional validation and replication.
Outcomes for patients with inborn errors of immunity (IEI) have improved dramatically over the last 30 years, largely due to earlier diagnosis and advances in targeted therapies. However, significant disparities persist, highlighting the need for continued ...
Stem cell transplantation remains the definitive treatment for ZAP70 deficiency, but outcomes vary. This single-center study offers practical insights into patient selection, conditioning regimens, and post-transplant monitoring to optimize results.
Newborn screening for T-cell lymphopenia identifies infants with potential immune deficiencies, but many have transient or non-severe conditions. This raises questions about the long-term implications and costs of monitoring those who may never develop sign...
Depression manifests differently across cultures, making standardized diagnostic tools potentially inadequate. This study highlights the necessity for culturally sensitive approaches to mental healthcare, particularly in chronic care settings.
Progressive multifocal leukoencephalopathy (PML) in patients with DOCK8 deficiency, while rare, carries a high risk of morbidity and mortality. Clinicians should maintain a high index of suspicion for PML in DOCK8-deficient individuals presenting with neuro...
The rising costs of orphan drugs for rare conditions like hereditary angioedema force payers to scrutinize safety data more intensely. Real-world evidence, despite its limitations, may increasingly dictate formulary placement for berotralstat and lanadelumab.