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In asthma and chronic rhinosinusitis with nasal polyps, inherited variation shapes airway inflammation. A large-scale genomic analysis reports 131 risk loci and enrichment in immune and epithelial tissues, pointing to type 2 and barrier-pathway mechanisms. ...
A large genetic analysis in asthma and nasal polyposis reports 131 loci , pointing to immune pathways and tissue-specific signals in airway biology. The findings emphasize mechanisms rooted in barrier-immune crosstalk and inflammatory signaling, underscorin...
In asthma and chronic rhinosinusitis with nasal polyps, shared immunologic mechanisms emerge as 131 loci converge on pathways spanning epithelial alarm signaling and eosinophilic inflammation. This genetic map underscores an airway continuum linking upper a...